The T8 antigen is a multimeric complex of two distinct subunits on human thymocytes but consists of homomultimeric forms on peripheral blood T lymphocytes.
The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes. Surface structures involved in target recognition by human cytotoxic T lymphocytes. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens.
Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function. Evidence from studies of CTL-target cell binding. Show 10 more references 10 of Smart citations by scite. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed. CD8 alpha is expressed by human monocytes and enhances Fc gamma R-dependent responses. The cytoplasmic domain of rat NKR-P1 receptor interacts with the N-terminal domain of p56 lck via cysteine residues.
Similar Articles To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation. Activation of human T lymphocytes. Triggering of bystander cytotoxicity in cytotoxic T cell clones by antibodies against the T3 antigen or by a calcium ionophore. T3 monoclonal antibody activation of nonspecific cytolysis: a mechanism of CTL inhibition. Anti-T3 antibody both activates and inhibits the cytotoxic activity of human T cell clones.
Joining Europe PMC. Tools Tools overview. ORCID article claiming. Journal list. Grant finder. External links service. Annotations submission service. Developers Developer resources. API case studies. SOAP web service. Annotations API. OAI service. Bulk downloads. Developers Forum. Search syntax reference. This mAb specifically inhibits the T and B cell antigen receptor-mediated lymphocyte activation. Lymphocyte activation under the microscope. Lymphozytenaktivierung unter dem Mikroskop.
The parameter for the rate of destruction of lymphocytes was the half-life of lymphocyte - activity determined from the 13th day onward. Tag an bestimmt wurde. By taking advantage of new microscopy techniques, consortium partners were able to visualise the actual process of lymphocyte activation in a living organism. Mittels neuer mikroskopischer Verfahren gelang es, den Prozess der Lymphozytenaktivierung unter dem Mikroskop am lebenden Organismus sichtbar zu machen.
It should be stressed that reciprocal lymphocytic activation is not limited to a species, but occurs in intra- and interspecific combinations from different donors.
Lymphocyte activation tests failed to detect drug-specific T cells, suggesting that the development of the rash was based upon a nonallergic drug hypersensitivity reaction. In the presence of B-lymphocytes, the assistance of T-cells is excluded. Dual-parameter FMF analysis of lymphocytes before and after in vitro activation.
PBL derived [rom nonimmune A and B or tuberculln- primed C pigs were analyzed before in vitro actlvatlon and after stimulation with eon A for 3 days A , with allogeneic stimulator cells for 7 daya B. On ordinate and abscissa, the relative log fluorescence lntensltles are expressed on ascale of 64 channels wlth 5 x cells analyzed.
Contour Iines represent levels of For PBL top, day 0 , double-negative cells are included In the fjeld below channel no. PE-label and to the left of channel no. For lymphoblasts bottom. The percentage of double-negative, double-positive, or single-positive cella Is Indlcated by the number in one corner of the respective quadrant.
Likewise, the T cell subsets. In its property to could be eliminated by antibody plus C treatment. In the absence of biochemical data. The expression of Lyt-1 is substantially enhanced be based on tissue distribution and functional properties. Antibody both subsets of porcine peripheral T lymphocytes but OKM 1 has been reported to react with human macro- also the increase in Lyt-1 antigen expression during T phages. After leukocytes and which also failed to precipitate the anti- antigen-specific or lectin-mediated stimulation, T cells gen has been isolated by Pescovitz et al.
This sug- temporarily lose homing receptors, including the MEL gested to us the possible identity of the antigens detected determinant For both of these antibodies, the respective porcine lymphocyte homing receptor. It is not clear whether the expression is related to the cell macrophages.
The ques- erythrocytes. It has been suggested that mAb 82A2 char- tion of whether the antigen is transiently or irreversibly acterizes recent thymus emigrant cells which populate down-regulated after activation is currently under study. This lymphocytes. It remains to be investigated whether this also ap- up- or down-regulated after activation by mitogen or pli es to immune responses in vivo. So far, this is only specific stimulation by antigen. Go stage of the cell cycle Certain dif- ferentiation antigens undergo quantitative variations in Acknowledgments.
The authors thank V. Ohlinger for the cell surface expression after activation. Down-regu- help with the animal experiments and S. Lymphocyte homlng receptors. Evolutionary conservatlon Cell Micklem, and L. Characterlzation of the Identlfled by mon- antigens two-parameter Immunofiuorescence and cytotoxlclty anal- oclonal antibody GK1.
Wo, R. Monoclonal antibodles IgG receptors on human pcripheral blood leukocytes by dual fluo- reactlve with swlne lymphocytes. Antibodies to membrane strnc- rescence flow mlcrofluorometry. Pescovitz, M. Preparatlon McKearn, and J. Murlne anti- Signals InvoIved In l' cell actlva- swlne 1'4 and T8 monoclonal antibodles: distribution and effects on tlon. Distlnct roles of Intact accessory cells. Interleukin 1 in actlvatlon and cell cycle progression of resUng T 7.
Surface Iymphocytes. Immunology Differential expres- 8. T cell development In the adult muTine thymus: changes In the expression of thc surface Immunoglobulin-related domalns for cell sur- antigens Ly2.
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