Nocturnal oxygen therapy trial 1980

The nocturnal oxygen therapy trial--NOTT. A case report of data monitoring experience: the nocturnal oxygen therapy trial.

Control Clin Trials. Psychologic effects of continuous and nocturnal oxygen therapy in hypoxemic chronic obstructive pulmonary disease.

Arch Intern Med. The lungs and causes of death in the nocturnal oxygen therapy trial. Recruitment experience in the Nocturnal Oxygen Therapy Trial. National Library of Medicine U. National Institutes of Health U.

In patients with COPD and hypoxemia, continuous oxygen therapy significantly reduces mortality when compared to nocturnal oxygen therapy. Therapies for COPD that were few in the s and included antibiotics, theophylline, ephedrine, the mucolytic potassium iodide, and phlebotomy. Participants had extensive evaluation of physiologic parameters at baseline and on regular intervals throughout the study.

With an average follow-up of Subsequent studies did not demonstrate a similar mortality benefit for milder hypoxemia. We conclude that in hypoxemic chronic obstructive lung disease, continuous O2 therapy is associated with a lower mortality than is nocturnal O2 therapy. The reason for this difference is not clear. Abstract At six centers, patients with hypoxemic chronic obstructive lung disease were randomly allocated to either continuous oxygen O2 therapy or hour nocturnal O2 therapy and followed for at least 12 months mean,